23andMe Is Sharing Its 5 Million Clients’ Genetic Data with Drug Giant GlaxoSmithKline

Popular genetics-testing company 23andMe is partnering with drug giant GlaxoSmithKline to use people’s DNA to develop medical treatments, the company announced in a blog post yesterday (July 25).

During the four-year collaboration, the London-based GlaxoSmithKline will use 23andMe’s genetic database to zero in on possible targets and treatments for human disease.

“The goal of the collaboration is to gather insights and discover novel drug targets driving disease progression and develop therapies,” GlaxoSmithKline said in yesterday’s statement, where it also reported it was investing $300 million in 23andMe. [How Do DNA Ancestry Tests Really Work?]

It’s not yet clear which conditions will be investigated during the collaboration, but one example showed how the collaboration might work: the two companies’ previous collaboration on the gene LRRK2, which is linked to some cases of Parkinson’s disease, Forbes reported.

Only about 10,000 of the 1 million Americans with Parkinson’s disease have the disease because of LRRK2. So, GlaxoSmithKline has to test about 100 Parkinson’s patients to find just one potential candidate. However, 23andMe has already provided 250 Parkinson’s patients who have agreed to be re-contacted for GlaxoSmithKline’s clinical trials, which may help the pharmaceutical company develop the drug much faster, Forbes reported.

However, not everybody is on board with 23andMe’s new partnership. If a person’s DNA is used in research, that person should be compensated, said Peter Pitts, president of the Center for Medicine in the Public Interest.

“Are they going to offer rebates to people who opt in, so their customers aren’t paying for the privilege of 23andMe working with a for-profit company in a for-profit research project?” Pitts said to NBC.

In addition, even though 23andMe gets the consent of its customers to use their genetic data, it’s unlikley that most people are aware of this.

“The problem with a lot of these privacy policies and Terms of Service is that no one really reads them,” Tiffany C. Li, a privacy expert and resident fellow at Yale Law School’s Information Society Project, told Tom’s Guide, a Live Science sister site. “You are paying to help the company make money with your data.”

The new collaboration isn’t the first time 23andMe’s vast pool of genetic data has been mined by scientists. The San Francisco startup has already published more than 100 scientific papers based on its customers’ data, according to yesterday’s blog post, by Anne Wojcicki, 23andMe’s co-founder and chief executive. In 2015, the company launched 23andMe Therapeutics, which focuses on developing “novel treatments and cures based on genetic insights from the consented 23andMe community,” Wojcicki wrote.

23andMe has more than 5 million customers worldwide who have had their DNA analyzed for ancestral data. People who would like to close their 23andMe accounts can go here, but the company notes that “any research involving your data that has already been performed or published prior to our receipt of your request will not be reversed, undone, or withdrawn.”

However, once a 23andMe account is closed, any spit samples that a person initially gave consent to be stored “will be discarded,” the company said.

Original article on Live Science.

 

https://www.livescience.com/63173-23andme-partnership-glaxosmithkline.html

10 REASONS ALCOHOL IS ACTUALLY POISON

https://addictionunscripted.com/10-reasons-alcohol-is-actually-poison/

Let’s face it, alcohol is glamorized in the media, in social settings, and in our everyday lives. Wherever you turn there are ads for alcohol, offers to get drinks or go to happy hours, and gifts of wine and liquor bottles. We hardly ever read about the dangers of alcohol unless it’s for the D.A.R.E. program, or trying to get kids to “just say no.” Articles that do bring up the dangers of alcohol consumption are often followed by jazzy headlines that read “a glass of wine a day is the same as one hour at the gym,” or “drinking alcohol prevents heart disease.” People are always looking for a way to justify drinking alcohol. I’m here to tell you, it’s worse than we thought. Here are 10 reasons why alcohol is actually poison.

1. ETHANOL ALCOHOL IS USED IN GASOLINE AND YOUR DRINKS

You read that right. Ethanol alcohol, the kind of alcohol that is used in pharmaceuticals, toiletries, and the fuel you put into your car, is the same type of alcohol that is in your martinis and your favorite beer. The anesthetic called ether is also made from ethanol. Another kind of alcohol, known as methanol, derived from similar chemical compounds as ethanol, is used as a solvent, as a raw material for producing formaldehyde, as well as antifreeze and for cleaning metals. Yuck!

2. ALCOHOL IS THE DIRECT CAUSE OF 7 FORMS OF CANCER

At the end of last year a study revealed that alcohol is the direct cause of 7 forms of cancer, not one, but 7. Health experts actually called for a warning label on alcohol products because the study, published in the journal Addiction, found that alcohol was the direct cause of liver, breast, oropharynx, larynx, esophagus, colon, and rectum cancer. Although the highest risk was seen in the heaviest drinkers, a considerable burden was still found in low to moderate alcohol consumption. The authors of the study concluded that there is no safe amount of alcohol to drink in reference to cancer.

3. 88,000 PEOPLE DIE ANNUALLY FROM ALCOHOL-RELATED CAUSES

This statistic is shocking and should alarm anyone who reads it. It means that alcohol is the fourth leading preventable cause of death in the United States. I mean, if orange juice was the fourth leading preventable cause of death in this country do you think there would be a movement to stop drinking? To not make fancy drinks with it? To make it look uncool? To not give it as a gift? You’re damn right there would be.

4. IT’S CALLED ALCOHOL POISONING FOR A REASON

Yes, alcohol is so toxic it can literally poison you. When your blood alcohol level is high enough, it is considered poisonous. This is because the liver is only made to process a limited amount of alcohol, one unit every hour. If you drink too much too fast your BAC can spike. One patient dies each week in the U.S. from alcohol poisoning. You can be at risk for alcohol poisoning even if you don’t binge drinking as it can even happen accidentally.

5. NO AMOUNT OF ALCOHOL IS SAFE WHILE PREGNANT

I’ve heard and seen pregnant women say that a glass of wine early on in their pregnancy won’t hurt. I’ve read articles about pregnant women being pressured to drink. The American Academy of Pediatrics, along with many other health organizations, have repeatedly said that prenatal exposure to alcohol is dangerous. In fact, as of 2015, it is the leading preventable cause of birth defects and intellectual and neurodevelopmental disabilities in children. A recent study found an increased risk of infant growth retardation even when a pregnant woman’s consumption was limited to one alcoholic drink per day. Some women believe drinking during the first trimester is harmless, but compared to no drinking, drinking during the first trimester results in 12 times the odds of giving birth to a child with FASDs.

6. ALCOHOL KILLS CELLS

This is why alcohol is used to clean stuff, to preserve food and to sterilize skin and needs. The toxicity of alcohol becomes greater when it is ready to be cleared from the body because it has to be metabolized to a substance called acetaldehyde. This substance is even more toxic than alcohol. The irony is, any food or drink contaminated with the amount of acetaldehyde that a unit of alcohol produces would be banned and outlawed immediately as having an unacceptable health risk.

7. DRINKING CAN LEAD TO ADDICTION

Although not everyone who drinks alcohol becomes addicted, there is a risk and the negative effects can be detrimental. In the current drinking climate, it’s difficult to understand when drinking becomes alcohol misuse or an alcohol use disorder. According to the NIAAA, as of 2015 15.1 million adults in the U.S. aged 18 or older have an alcohol use disorder. It can be argued that other substances that are prescribed or taken daily can also cause an addiction, pain pills, food, etc. However, alcohol is unique in that we know it’s a drug and we glamorize it anyway.

8. DRINKING IN EXCESS ON ONE OCCASION CAN TAKE A TOLL ON YOUR HEALTH

We often hear drinking only one can’t hurt us, but it can. Alcohol can interfere with the brain’s communication pathways and can affect how the brain looks and works. Drinking a large amount over a long time or too much on one occasion can damage the heart including issues such as cardiomyopathy, arrhythmias, stroke, and high blood pressure. Heavy drinking over time can lead to even more adverse health consequences.

9. ALCOHOL CAUSES ORGANS IN THE BODY TO PRODUCE TOXIC SUBSTANCES

Alcohol actually causes the pancreas to produce toxic substances that can lead to pancreatitis, a dangerous swelling of the blood vessels in the pancreas that impedes proper digestion. Moreover, I already mentioned how the alcohol we metabolize also converts into a toxic substance, acetaldehyde.

10. YOUR BODY SEES ALCOHOL AS A POISON

When alcohol enters your body, your body sees it as a poison and it automatically reacts by attempting to fight back. To sober you up, the body produces an enzyme called alcohol dehydrogenase. The body goes after alcohol once it passes through the stomach lining into the liver. That’s where it changes into acetaldehyde. Acetaldehyde is thought to be the cause of nasty hangovers.

As you can see, any way you slice it alcohol is poison. Its effects are far-reaching and devastating. Personally, I believe it’s time to stop acting like drinking is the normal thing to do and treat is like what it really is: poison.

North Carolina man who slept with married woman must pay her husband $8.8 million

Dafuq?

 

A man who slept with a married woman has been ordered by a judge to pay a whopping $8.8 million to her husband who owns a BMX bike stunt show company.

Francisco Huizar III was forced to pay Keith King — the man he cuckolded — $2.2 million in compensatory damages and $6.6 million in punitive damages, The Herald Sun reported.

Huizar’s attorney said they will appeal Superior Court Judge Orlando Hudson’s ruling, according to the report.

King was married to Danielle King, with whom he shares a 5-year-old daughter, in 2010. But Danielle claims the North Carolina couple was neverhappy,and had separated in August 2016.

King in April 2017 accused Huizar of criminal conversation, alienation of affection, intentional infliction of emotional distress, negligent infliction of emotional distress and assault and battery, according to the report.

His attorney, Joanne Foil, said Huizar’s affair with King’s wife, who was an employee of BMX Stunt Shows, cost the company an employee and also revenue as he incurred expenses including household help, child care and counseling.

Cheri Patrick, an attorney for Huizar, meanwhile argued that her client could not be blamed for disrupting a marriage that was broken well before he came along.

“This marriage needed one more blow before it was over,” Patrick said.

Danielle King alleged in her testimony that she pursued Huizar, whom she met at a BMX competition in New York.

King suspected an affair after seeing calls on his wife’s phone log to a strange number.

He contacted Huizar and asked him to stop contacting his wife, at which point he believed their affair was over, Foil said, The Herald Sun reported.

The extramarital affair continued, however, to the point that the marriage could not “have humanely been saved with the level of this man’s involvement,” Foil said.

King alleges he visited his wife at an apartment she had rented where Huizar put him in a choke hold.

Foil argues that King developed post-traumatic stress disorder as a result.

http://www.nydailynews.com/news/national/ny-news-man-married-woman-20180727-story.html